A barbiturate overdose results when a person takes excessive doses of barbiturates. Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness, shallow breathing, and staggering. In severe cases, coma and death can result. The lethal dosage of barbiturates varies greatly with tolerance and from one individual to another.
Barbiturate overdose with other CNS (central nervous system) depressants, such as alcohol, opiates or benzodiazepines, is even more dangerous due to additive CNS and respiratory depressant effects. In the case of benzodiazepines, barbiturates also increase the binding affinity of the benzodiazepine binding sites thus leading to an exaggerated effect of benzodiazepines. This makes the predicting the effect of combinations difficult and the same dose of the same drugs will not always produce the same degree of sedation and respiratory depression as the previous experience.
Benzodiazepines increase the frequency of chloride channel opening while barbiturates increase the duration that the chloride pore remains open. If a normal pore opened once every 30 seconds to pass one chloride ion, a benzodiazepine may cause it to open once every ten seconds while a barbiturate may cause it to remain open until three ions have passed through. Separately, both of these increase the effect of the pore threefold, but together, the channel would allow three ions to pass every 10 seconds. This would exponentially increase the effect of the pore ninefold, greater than the sum of the two drugs effects.
The treatment of barbiturate abuse or overdose is generally supportive. The amount of support required depends on the person's symptoms. If the patient is drowsy but awake and can swallow and breathe without difficulty, the treatment can be as simple as monitoring the patient closely. If the patient is not breathing, it may involve mechanical ventilation until the drug has worn off.
Supportive treatment often includes the following:
- Activated charcoal may be given via nasogastric tube.
- Intravenous administration of saline, naloxone, thiamine, and/or glucose.
- NaHCO3 to alkalize the urine to increase rate of excretion.
- Intubation and bemegride, or a hand-breather where these are not available until the patient can breathe under their own power.
- Observation in the Emergency Department for a number of hours or admission to the hospital for several days of observation if symptoms are severe.
- Advise the patient about drug misuse or refer for psychiatric consult.
In famous cases, Marilyn Monroe, Dalida, Judy Garland, Jimi Hendrix, and also Edie Sedgwick died from a barbiturate overdose.
See also
- Bemegride, an analeptic used to treat acute Barbiturate overdose
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