ARIAD Pharmaceuticals, Inc. is an oncology company founded in 1991 and headquartered in Cambridge, Massachusetts. On December 14, 2012 the FDA approved Ariad Pharmaceuticalâs leukemia drug Iclusig for patients with all forms of chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia who are resistant or unable to tolerate other tyrosine kinase therapies on the market.
Ariad has strong partnerships with Merck and is engaged in the discovery, development, and commercialization of medicines for cancer patients. It offers Iclusig (ponatinib), a tyrosine kinase inhibitor for the treatment of adult patients with chronic myeloid leukemia (CML), and Philadelphia chromosome-positive acute lymphoblastic leukemia in the United States and Europe. The company is also developing Iclusig for other blood cancers and solid tumors, such as gastrointestinal stromal tumors, acute myeloid leukemia, and certain forms of non-small cell lung cancer; and various investigator-sponsored trials in indications, including first line and second line CML, acute myeloid leukemia, non-small cell lung cancer, and medullary thyroid cancer. In addition, its product pipeline consists of Brigatinib, an investigational inhibitor of anaplastic lymphoma kinase for treating advanced solid tumors comprising non-small cell lung cancer; and Ridaforolimus, an investigational mTOR inhibitor for various types of cancers. The company sells and markets Iclusig through specialty pharmacies and specialty distributors in the United States. It has collaboration and license agreement with Merck & Co., Inc. for the development, manufacture, and commercialization of ridaforolimus for use in cancer; and license agreements with Medinol Ltd. and ICON Medical Corp. to develop and commercialize stents and other medical devices to deliver ridaforolimus.
On February 21, 2014 Ariad Pharmaceuticals announced the appointment of Sarissa Capitalâs Alexander J. Denner, Ph.D. to a two-year term on the Companyâs Board of Directors. Previously, Dr. Denner served as a senior managing director at Carl Icahn's Icahn Capital and is currently Ariadâs second-largest shareholder.
On May 15, 2014, Ariadâs Board of Directors enacted an amendment to its Section 382 Rights Agreement allowing investment firm BlackRock, Inc. the right to acquire more than 4.99% of the common stock in the company.
Products
FDA-approved products
- Ponatinib (Iclusig)
Products under development
- Ridaforolimus (formerly Deforolimus, partnered with Merck)
- Brigatinib (formerly AP26113)
See also
- Merck
- Bristol-Myers Squibb
- Pfizer
References
External links
- Official ARIAD site
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